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  • Title: Replication of T4 DNA in Escherichia coli treated with toluene.
    Author: Miller RC, Taylor DM, MacKay K, Smith HW.
    Journal: J Virol; 1973 Dec; 12(6):1195-203. PubMed ID: 4586770.
    Abstract:
    Deoxyribonucleoside triphosphates are incorporated into T4 DNA in infected cells treated with toluene. Under the proper conditions the incorporation is controlled by the known T4 DNA polymerase and proceeds by a semiconservative mechanism. Both strands of the phage DNA are replicated into a high molecular weight progeny molecule. The replication system is accessible to extracellular pancreatic DNase added to the reaction mixture. At early times after infection a second replication system, not under control of the gene 43 polymerase, has been detected which synthesizes T4 DNA in toluenized cells.
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