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  • Title: Tumor development after 3-methylcholanthrene in immunologically deficient athymic-nude mice.
    Author: Stutman O.
    Journal: Science; 1974 Feb 08; 183(4124):534-6. PubMed ID: 4588620.
    Abstract:
    Athymic-nude (nu/nu) mice and normal (nu/+) mice showed no differences in either latent period or incidence of local sarcomas or lung adenomas within 120 days after administration of 3-methylcholanthrene at birth. However, nu/nu mice were incapable of rejecting allogeneic skin grafts for the duration of the experiment. These results argue against an active role of thymus-dependent immunity as a surveillance mechanism preventing tumor development.
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