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  • Title: Endocrine assessment of post-pill amenorrhoea.
    Author: Newton J, Curson R.
    Journal: Proc R Soc Med; 1973 Jun; 66(6):567-9. PubMed ID: 4592764.
    Abstract:
    24 cases of postpill amenorrhea are presented. The patients were 17-34 years of age and the length of amenorrhea was 6-60 months with a mean of 13.4 months. There was no relationship between the type of contraceptive pill, length of usage, and the incidence of amenorrhea which suggests that the mechanism of action is general rather than due to a specific combination of steroid hormones. The basal endocrine status of the thyroid and adrenal was normal. 14 of the patients had low estrogen and gonadotropins and of these only 4 had a positive clomiphene pituitary reserve test. These 4 patients subsequently restarted normal cycles and luteinizing hormone/follicle stimulating hormone-releasing hormone tests showed normal pituitary function, indicating that the others probably had some derangement of hypothalamic pituitary function.
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