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  • Title: Benign cholestatic jaundice of pregnancy and benign cholestatic jaundice from oral contraceptives.
    Author: Drill VA.
    Journal: Am J Obstet Gynecol; 1974 May 15; 119(2):165-74. PubMed ID: 4595936.
    Abstract:
    A discussion of benign cholestatic jaundice of pregnancy and from oral contraceptives is presented. It has been established that recurrent cholestatic jaundice of pregnancy is caused by interference with liver secretory processes such that conjugated bilirubin accumulates in the blood stream. The condition maybe caused by a possible inherited metabolic effect resulting in an increased secretion of estrogen and progesterone. Women with a history of cholestatic jaundice of pregnancy may experience generalized pruritus or cholestatic jaundice if they are on an oral contraceptive regimen. Pruritus may be a symptomatic sign of the onset of cholestatic jaundice and in women using oral contraceptives, the condition indicates the possible development of choletic jaundice during pregnancy. Cholestatic jaundice will usually disappear 1 to 8 weeks after parturition or the cessation of oral contraceptive therapy.
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