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  • Title: Propranolol in the treatment of migraine.
    Author: Wideroe TE, Vigander T.
    Journal: Br Med J; 1974 Jun 29; 2(5921):699-701. PubMed ID: 4604977.
    Abstract:
    Beta-blocking drugs that prevent cranial vasodilatation are potentially valuable in the prophylaxis of migraine. Forty-nine patients with either classic or common migraine were treated with propranolol 160 mg/day for an average of six months. The first 30 of the patients to respond well to this treatment then participated in a double-blind cross-over trial with a placebo and propranolol. The mean frequency of headache attacks was significantly reduced by propranolol. None of the patients expressed a preference for placebo. Propranolol seems to be an effective prophylactic for common and classic migraine but the antimigraine properties of the various beta-blocking agents probably differ.
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