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  • Title: Role of ATP in excision repair of ultraviolet radiation damage in Escherichia coli.
    Author: Waldstein EA, Sharon R, Ben-Ishai R.
    Journal: Proc Natl Acad Sci U S A; 1974 Jul; 71(7):2651-4. PubMed ID: 4605075.
    Abstract:
    The effect of ATP on the first step of excision repair of ultraviolet damage in DNA has been studied using toluene-treated E. coli. During postirradiation incubation, five to six times more single-strand breaks are formed in DNA in the presence of exogenous ATP than in its absence. The ATP-dependent as well as the ATP-independent endonucleolytic activities appear to be catalyzed by the same enzyme since both activities are almost completely absent in uvrA and uvrB mutants. An ATP-dependent endonucleolytic activity has been detected in nonirradiated toluene-treated E. coli. It is concluded that ATP is required in vivo for either the incision step of repair or an enzymatic reaction preceding it.
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