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  • Title: T cell-dependent mediator in the immune response. II. Physical and biological properties.
    Author: Waldmann H, Munro A.
    Journal: Immunology; 1974 Jul; 27(1):53-64. PubMed ID: 4605203.
    Abstract:
    Supernatants were obtained from cultures of keyhole limpet haemocyanin (KLH) primed mouse spleen cells, and also from cultures of KLH-educated, thymus-derived lymphocytes (T cells) after re-exposure of cells to the original priming antigen, KLH. These supernatants were able to facilitate the immune response of bone marrow-derived lymphocytes (B cells) to sheep erythrocytes (SRBC). Certain physical and biological properties of such supernatant activities are described.
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