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  • Title: Medical manipulation of the ductus arteriosus.
    Author: Elliott RB, Starling MB, Neutze JM.
    Journal: Lancet; 1975 Jan 18; 1(7899):140-2. PubMed ID: 46053.
    Abstract:
    Prostaglandin E-1 was infused into two children with cyanotic congenital heart-disease where patency of the ductus arteriosus was necessary to maintain arterial oxygen saturation. With each infusion oxygen saturation rose, probably as a result of dilatation of the ductus. Administration of the non-specific antagonist of prostaglandin synthesis, indomethacin, to one patient was associated with a fall in arterial saturation. The prevention of ductus closure by p.g.E-1 infusions over the first few weeks of life is a possiblility.
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