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  • Title: Mitochondrial genetics in Bakers' yeast: a molecular mechanism for recombinational polarity and suppressiveness.
    Author: Perlman PS, Birky CW.
    Journal: Proc Natl Acad Sci U S A; 1974 Nov; 71(11):4612-6. PubMed ID: 4612525.
    Abstract:
    Recombinational polarity and suppressiveness are two well-known but puzzling cytoplasmic genetic phenomena in bakers' yeast, Saccharomyces cerevisiae. Little progress has been made in characterizing the underlying molecular mechanisms of these phenomena. In this paper we describe a molecular model for recombinational polarity that is compatible with the available genetic evidence. The model stresses the role of small deletions and excision/repair processes in otherwise canonical recombinational events. According to the model, both phenomena require recombination and may share mechanistic elements.
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