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  • Title: Induction of abortion by intrauterine administration of prostaglandin F2 alpha and histopathological studies of gestational sac.
    Author: Hingorani V, Dua A, Bhuyan UN.
    Journal: Contraception; 1974 Jul; 10(1):13-23. PubMed ID: 4613531.
    Abstract:
    124 patients were selected for termination of pregnancy by (PGF) prostaglandin F2alpha administration. PG was administered by the extraamniotic route in 81 patients, whose length of gestation ranged from 8-16 weeks. PG was administered intraamniotically in 43 patients whose length of gestation ranged from 14-20 weeks. In the extraamniotic group, abortion occurred in 89% of the cases within 36 hours with a mean induction-abortion interval of 18 hours. In the intraamniotic group, abortion occurred in 86% of the cases within 48 hours with a mean induction-abortion interval of 20 hours. Histopathological studies on gestational sacs were performed in 3 groups of patients: in group 1 abortions were induced by PGF2alpha administered extraamniotically; in group 2 abortions were induced by PGF2alpha administered intraamniotically; and in group 3 specimens were obtained by hysterotomy. Edema of villi was more often observed in group 1 and increased vascularization in group 2.
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