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  • Title: [Sex hormone regulation of progesterone and estradiol receptors in the cytosol of human endometrium in normal and pathologic pregnancy].
    Author: Iudaev NA, Asribekova MK, Karpova SK, Kaganovich BE.
    Journal: Probl Endokrinol (Mosk); 1979; 25(3):37-42. PubMed ID: 461380.
    Abstract:
    Hormonal control of progesterone and estradiol receptors was studied in the cytozol of short-lived culture of human endometrium in normal and undeveloping pregnancy. Endometrium was cultivated in the presence of estradiol or progesterone for 16 hours. In cultivation of normal endometrium with estradiol the content of estradiol receptors increased 4-fold in comparison with unstimulated tissue, and of progesteron receptors--3-fold. In cultivation of normal endometrium with progesterone the content of estradiol receptors rose 4--5-fold, and of progesterone receptors--3-fold. In cultivation of pathological endometrium with estradiol or progesterone the number of estradiol receptors was only doubled, and of progesterone receptors--increased only 1 1/2 times, this pointing to a diminished sensitivity of pathological endometrium to the regulating action of sex hormones. Hormonal control of progesterone and estradiol receptors was studied in the cytozol of a short-lived culture of human endometrium in both normal and undeveloping pregnancy. Endometrium was cultivated in the presence of estradiol or progesterone for 16 hours. In the cultivation of the normal endometrium with estradiol, the content of estradiol receptors increased 4-fold in comparison with the normal tissue, and the progesterone receptors increased 3-fold. In the culturation of the normal endometrium with progesterone, the content of the estradiol receptors rose 4-5-fold while the progesterone receptors increased 3-fold. In the cultivation of the pathological endometrium with either estradiol or progesterone, the number of estradiol receptors only doubled and the progesterone receptors increased only 1-1/2 times. This points to a diminished sensitivity of a pathological endometrium to the regulating action of sex hormones. (Authors' modified)
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