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  • Title: On the regulation of antipyrine and oxazepam metabolism in man.
    Author: Kellermann GH, Luyten-Kellermann M.
    Journal: Res Commun Chem Pathol Pharmacol; 1979 Feb; 23(2):287-96. PubMed ID: 461954.
    Abstract:
    The metabolism of antipyrine and oxazepam has been measured in twelve healthy subjects. Antipyrine, an analgesic and antipyretic drug, is extensively metabolized by oxidation at various sites and oxazepam, a benzodiazepine, is almost exclusively metabolized by conjugation with glucuronic acid. Comparing the plasma clearance rates and the plasma half lives of the two drugs, correlation coefficients of r = 0.766 (P less than 0.01) and r = 0.966 (P less than 0.01) have been obtained. The data suggests that in man the processes of oxidation and glucuronidation are linked by a common control which regulates the metabolic rates of the two reactions.
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