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  • Title: Reactivity to calcitonin after ovariectomy.
    Author: Gozariu L, Florescu O, Toader S.
    Journal: Endocrinologie; 1979; 17(2):133-5. PubMed ID: 462110.
    Abstract:
    The hypocalcemic response to calcitonin injected in female rats disappeared after their castration. The substitution treatment with estrogens does no allow reestablishment of the hypocalcemic effect obtained in intact animals, a fact that lays stress on the role of the whole ovarian secretion in maintaining a normal response to calcitonin. The response of castrated animals to calcitonin calls attention to the conditional role of estrogens in validating the osteoprotecting effect of calcitonin.
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