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  • Title: Effects of metronidazole on certain functions of human blood neutrophils and lymphocytes.
    Author: Anderson R, Oosthuizen R, Maritz C, Theron A, Van Rensburg AJ.
    Journal: S Afr Med J; 1979 Apr 07; 55(15):593-6. PubMed ID: 462263.
    Abstract:
    The effects of metronidazole at varying concentrations (10(-7)M - 10(-2)M) on certain cellular immune functions were assessed in vitro. Neutrophil chemotaxis to endotoxin-activated autologous serum, random motility and postphagocytic metabolic activity (hexose monophosphate shunt activity, myeloperoxidase-mediated protein iodination and glycolysis) were unaffected. Likewise, metronidazole had no detectable effects on lymphocyte-active E-rosette formation, mitogen-induced DNA synthesis and mitogen-induced protein synthesis.
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