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  • Title: Induction of amyloidosis in germ-free NMRI-mice after prolonged stimulation with sterilized casein.
    Author: Claesson MH, Hardt F.
    Journal: Clin Exp Immunol; 1972 Jun; 11(2):277-81. PubMed ID: 4625160.
    Abstract:
    Repeated injections of casein are known to induce amyloidosis in conventionally kept mice. The influence of germfree environments on the induction time and the development was studied. The induction time was considerably longer for the group of germfree mice than for the conventional group, however the development of amyloidosis followed the same pattern in both groups, resulting in deposits of amyloid in spleen, liver and kidneys. The two groups of mice did not show significant differences in the amounts of anti-casein antibodies produced during the period of casein treatment. Furthermore, no correlation between antibody production and amyloid formation was observed. Infections with bacteria and fungi seem not to play any important part in the pathogenetic mechanisms of amyloidosis.
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