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  • Title: [Change in the selectivity of the sodium channels of a nerve fiber membrane under the action of veratrine].
    Author: Naumov AP, Neguliaev IuA, Nosyreva ED.
    Journal: Tsitologiia; 1979 Jun; 21(6):692-6. PubMed ID: 462545.
    Abstract:
    The ionic currents of the nodal membrane were measured under voltage clamp conditions. The membrane being +40 mv. The replacing of the external Na+-ions to K+- and NH4+-ions have showed that the relative pearmeabilities of the veratrine-modified channels calculated from the constant field theory are arranged in the following row: PNa:PK:PNH4 = 1:0.29:0.61, which differs from the same row for the normal channels. The decreasing of the slope of current-voltage relations of the modified channels with the replacing of Na+-ions to K+- and NH4+-ions is the evidence of a more strong binding of these ions to external mouth of the modified channel compared to the binding of Na+-ions.
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