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Title: Multicentre, short-term therapeutic trial of disodium cromoglycate, with and without prednisone, in adults with asthma. Author: Gebbie T, Harris EA, O'Donnell TV, Spears GF. Journal: Br Med J; 1972 Dec 09; 4(5840):576-80. PubMed ID: 4629980. Abstract: A total of 117 asthmatic patients were studied in a double-blind, cross-over trial with half-periods of three weeks in which disodium cromoglycate (D.S.C.G.) was compared with an inactive preparation. D.S.C.G. improved spirometric measurements, at a very high level of statistical significance, more than did placebo. The mean advantage of D.S.C.G. was less than 10% after three weeks. Symptomatic improvement by D.S.C.G. was small though significant; it was not correlated with spirometric improvement. A history of chronic cough was the only clinical characteristic associated with a better-than-average spirometric response to D.S.C.G.[Abstract] [Full Text] [Related] [New Search]