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  • Title: Intravenous prostaglandin F2 for therapeutic abortion: the efficacy and tolerance of three dosage schedules.
    Author: Brenner WE.
    Journal: Am J Obstet Gynecol; 1972 Aug 15; 113(8):1037-45. PubMed ID: 4635173.
    Abstract:
    To determine the most optimal procedure for use of prostaglandins (PGs) clinically for abortion, the abortifacient efficacy and complications of 3 types of intravenous PGF2 alpha schedules were compared over 18 hours. 17 healthy women from 7-20 weeks gestation were infused with PGF2 alpha for therapeutic abortion. The subjects were divided into 3 groups: 1 receiving a constant infusion beginning at 25 mcgm/minute increasing to 200 mcgm up to the maximum FDA dose; the second receiving progressive doses at specified times until the patient developed 350 Montevideo units (MU) of uterine activity; and the third receiving 25 mcgm/minute for 1/2 hour followed by maintenance at 50 mcgm/minute until abortion. All patients aborted with the low-dosage schedule and there were fewer complications. No difference in uterine contractility was seen among subjects receiving the 3 dosage schedules or between those patients aborting and those who failed to abort.
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