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  • Title: Divergence of opinion on placental damage due to hypertonic saline-induced abortion.
    Author: Manabe Y, Nakajima A.
    Journal: Am J Obstet Gynecol; 1972 Dec 15; 114(8):1107-8. PubMed ID: 4635209.
    Abstract:
    The issue of the mode of efficacy of hypertonic saline-induced abort ion during midpregnancy is discussed. Some investigators claim the procedure results in severe damage to the placenta and a consequent reduction in progesterone synthesis, while others claim that these effects are minimal, if present. The confusion can be eliminated, it is claimed, if the following experimental saline and the volume infused, 2) the thickness and size of the placenta, 3) the total volume of amniotic fluid, 4) the amount of amniotic fluid removed before saline infusion, and 5) the duration of exposure. It is important to properly select the experimental paramters for hypertonic saline abortion in order to minimize its inherent danger.
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