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  • Title: The effect of prostaglandin F2 alpha infusion on corpus luteum function.
    Author: Jones GS, Wentz AG.
    Journal: Am J Obstet Gynecol; 1972 Oct 01; 114(3):393-404. PubMed ID: 4637460.
    Abstract:
    The effect of prostaglandin (PG) F2 alpha on corpus luteum function in normal women with regular menstrual cycles was investigated. 21 women were recruited as volunteers and PGF2 alpha was infused for 8 hours (25 mgm). Infusions were given between Day 14 and 27 of the luteal phase of the cycle, with Day 14 arbitrarily considered the time of ovulation. 13 of 21 women showed a shortened luteal phase of at least 1 day or less. 1 of 2 women, given PGF2 alpha before ovulation, failed to ovulate, and 2 other patients had anovulatory cycles in the immediate postinfusion cycle. Steroid parameters (serum progesterone, urinary pregnanediol, and serum estradiol) failed to show a consistent change. Measurements of serum progesterone and estradiol during infusion showed an initial depression and subsequent elevation of steroid levels measured. It is concluded that an 8-hour infusion of PGF2 alpha in women fails to disrupt corpus luteum function.
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