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  • Title: Identification of differing etiologies of clinically diagnosed premature menopause.
    Author: Board JA, Redwine FO, Moncure CW, Frable WJ, Taylor JR.
    Journal: Am J Obstet Gynecol; 1979 Aug 15; 134(8):936-44. PubMed ID: 463997.
    Abstract:
    Investigations were performed in eight young women to determine if the findings of secondary amenorrhea and high follicle-stimulating hormone levels were due to primary ovarian follicular atresia or to other causes. Karyotypes were determined from both peripheral leukocytes and ovarian tissue; one woman had XXX/XX/XO mosaicism. Another woman had normal ovarian histology and probably had the "gonadotropin-resistant ovary syndrome." No autoimmune antibodies were detected, but one woman with myasthenia gravis also had ovarian histology that demonstrated primary ova and a developing follicle. Only five of eight women had primary ovarian follicular atresia, and two of the other three women had conditions theoretically compatible with subsequent pregnancy.
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