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  • Title: Computer simulation of after-inhibition in crayfish slowly adapting stretch receptor neuron.
    Author: Sokolove PG.
    Journal: Biophys J; 1972 Nov; 12(11):1429-51. PubMed ID: 4642221.
    Abstract:
    A theoretical model is described which is able to mimic the responses of slowly adapting stretch receptor neurons of crayfish to applied currents. Its principal feature is postspike inhibition, in which each nerve impulses produces a small inhibitory current that decays with a simple exponential time-course that is long compared with normal interspike intervals. The model was simulated with both an analogue and a digital computer. Parameters for particular model neurons were determined both by an analysis of experimental data obtained from adaptation to constant injected currents, and by matching computer output to the data. Parameter values estimated by the two techniques agreed within +/-10%. Model parameters determined from adaptation data successfully predicted the magnitude and time-course of posttetanic hyperpolarization (PTH) in the stretch receptor neuron. In addition, model neurons were able to reproduce posttetanic depression (PTD) as seen in stretch receptor cells.
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