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  • Title: Absence of synergism between exposure to asbestos and cigarette smoking in asbestosis.
    Author: Samet JM, Epler GR, Gaensler EA, Rosner B.
    Journal: Am Rev Respir Dis; 1979 Jul; 120(1):75-82. PubMed ID: 464386.
    Abstract:
    To assess both independent and synergistic effects of exposure to asbestos and cigarette smoking on the development of asbestosis, survey data from 4 groups of workers exposed to asbestos were analyzed with multivariate statistical models. Survey methods were standardized and included for the 383 subjects a respiratory symptoms questionnaire, occupational history, physical examination, pulmonary function testing, and a chest radiograph. Exposure to asbestos and cigarette smoking were assessed by questionnaire. Synergism between the 2 exposures was not present for previously identified manifestations of asbestosis including bilateral fine crackles, clubbing, dyspnea, radiographic abnormality, decreased forced vital capacity, and decreased single-breath diffusing capacity of the lung for CO. However, additive, independent effects of these 2 exposures were present for each of these parameters.
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