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  • Title: [Mexiletine, a drug with anti-arrhythmic action. Experimental research on the cardiovascular system].
    Author: Caputi AP, Rossi F, Lampa E, Imperatore A, Visone C, Marmo E.
    Journal: Arch Sci Med (Torino); 1979; 136(1):1-15. PubMed ID: 464786.
    Abstract:
    It was shown experimentally that mexilithene possesses anti-arrhythmic activity with slight depression of sino-carotid baroreceptorial and glomo-carotid and gangliar chemoreceptorial activity and catecholamine uptake. Hypotensive and bradycardizing effects were only noted when high per kg doses were used. The drug did not display vascular alpha- and beta-adrenolytic, anti-muscarinic and anti-histaminic activity.
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