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  • Title: The development of antigen-binding lymphocytes in foetal tissues.
    Author: Dwyer JM, Mackay IR.
    Journal: Immunology; 1972 Dec; 23(6):871-9. PubMed ID: 4648854.
    Abstract:
    The time of appearance and counts of antigen-binding cells, using radioiodine-labelled flagellin and haemocyanin, was studied in the human and mouse foetus at different gestational ages: the capacity for binding radioiodine-labelled antigens was equated with acquisition of immunological funciton. Cells resembling lymphocytes from human and mouse liver and bone marrow showed antigen binding at early gestational ages, but this binding could not be prevented with species-specific antisera to immunoglobulins. Specific antigen binding to lymphocytes was detected first with thymic lymphocytes, at gestational ages of 12 weeks in humans and 14 days in mice, then with splenic lymphocytes, at 16 weeks in humans and 17 days in mice, and still later with gut lymphocytes. Relative counts of antigen-binding cells in human foetal thymus were maximal at 16–22 weeks and decreased thereafter. Lymphocyte immunocompetence, as judged by the capacity specifically to bind antigen, develops rapidly after the appearance in thymus of cells with the morphology of lymphocytes; this seemed to occur at the equivalent foetal stage in the species studied.
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