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  • Title: The binding of calcium to fibrinogen: influence on the clotting process.
    Author: Marguerie G, Benabid Y, Suscillon M.
    Journal: Biochim Biophys Acta; 1979 Jul 25; 579(1):134-41. PubMed ID: 465525.
    Abstract:
    The influence of Ca2+ on the basic reaction between thrombin and fibrinogen was investigated. The results demonstrate that: (a) A Ca2+-dependent dimeric intermediate is formed during the early step of the clotting process. This dimeric intermeidate is shown to be formed by the association of an intact fibrinogen molecule and a fibrin monomer devoid in only the peptide A, (b) Ca2+ enhances the proteolytic step as illustrated by the measure of the kinetics of H+ release at pH 8.6. On the basis of these observations it is proposed that Ca2+ catalyses the proteolysis of fibrinogen by thrombin through the formation of a Ca2+-dependent dimer.
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