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  • Title: Uterine and mammary neoplasia and other changes (amyloidosis) in C3H mice, related to ovariectomy, estrogen and methylcholanthrene.
    Author: Wessely Z, Klavins JV.
    Journal: Oncology; 1972; 26(1):33-52. PubMed ID: 4670914.
    Abstract:
    The hypothesis that estrogen might decrease the incidence of 20-methylcholanthrene (MC)-induced carcinomas by preventing dysplasias or even intraepithelial carcinomas, which in animals not receiving estrogen would progress to invasive carcinoma, was tested in C3H mice. The effects of castration on cervical neoplasia were also observed in the mice. In the 48-week experimental period, there was no significant difference (p greater than .1) in the incidence of squamous cell carcinoma between animals receiving estrogen (31%) and not receiving estrogen (28%). However, when the animals were castrated, the incidence of carcinoma for the entire period was only 14%, significantly less (p less than .05) than in animals receiving estrogen, but not sufficiently different from the group of animals receiving MC only (p greater than .1). The differentiation of invasive squamous cell carcinoma was better when the animals were injected with estrogen and less differentiated when they were castrated. Dysplasia and pseudoepitheliomatous hyperplasia were seen more frequently in the animals receiving MC without estrogen or castration. Estrogen increased the PAS-positive material (probably neutral mucopolysaccharides) in the endometrial stroma and the acid mucopolysaccharides in the cervical subepithelial tissues. The increase of these ground substances accounted for an increase in the size of the uterus. Presence of endometrial hyperplasias, endometrial carcinomas, mammary carcinomas, and liver amyloidosis was associated with the estrogen administration. Mammary carcinomas were related to the MC application to cervix and amyloidosis of liver to the presence of carcinomas. 2 spontaneously occurring ovarian neoplasms were observed.
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