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  • Title: 6-Hydroxydopa depletion of brain norepinephrine and the function of aggressive behavior.
    Author: Thoa NB, Eichelman B, Richardson JS, Jacobowitz D.
    Journal: Science; 1972 Oct 06; 178(4056):75-7. PubMed ID: 4672239.
    Abstract:
    A significant increase in shock-induced aggression occurs in the rat 4 days after an intraventricular injection of 90 micrograms of 6-hydroxydopa. Both fluorescent histology and biochemical assay demonstrate that brain norepinephrine is reduced by 90 micrograms of 6-hydroxydopa, while brain dopamine remains unaltered. This suggests that one form of aggressive behavior (shock-induced aggression) is modulated through a central noradrenergic system.
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