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  • Title: [Changes in the perfusion of the internal organs of rabbits with experimental atherosclerosis treated with a protein hydrolysate].
    Author: Demireva K, Popdimitrov I.
    Journal: Eksp Med Morfol; 1979; 18(2):68-71. PubMed ID: 467309.
    Abstract:
    The authors examined the vascularization of the internal organs of rabbits with experimental atherosclerosis, induced by the method of Sapirstein with 86-Rubidium. The experiments were carried out on male rabbits of the strain Cincilla, fed with cholesterol in a dose of 0.2 gm/kg of body weight daily for a period of 90 days. Part of the animals were treated with protein hydrolysate in a dose of 5 ml/kg of body weight subcutaneously, but the remaining part of the animals-with saline. There was a reduced vascularization in heart, kidney, intestine, liver, adrenals, pancreas, and other internal organs in rabbits fed with cholesterol and treated with saline. Administration of protein hydrolysate had protective effect on the vascularization of the organs accumulation of 86-Rubidium in a large part of the animals presented values higher than rhose of the control group. The authors suggested that under the influence of amino-acids from the protein hydrolysate the state of the endothelial cells was stabilized and the local, feactions of vascularization were stimulated as well.
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