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  • Title: Indications for a brain uptake of labelled vasopressin and ocytocin and the problem of the blood-brain barrier.
    Author: Landgraf R, Ermisch A, Hess J.
    Journal: Endokrinologie; 1979 Feb; 73(1):77-81. PubMed ID: 467364.
    Abstract:
    Fifteen seconds after intracarotid injection of [125J]-lysine vasopressin, [3H]-ocytocin, tritiated water or [3H]-inulin, the distribution of radioactivity in 18 regions of the rat brain and in the anterior pituitary was determined. Comparing the concentration of the different tracers (in % of injected radioactivity per g brain tissue), it is assumed that a small amount of the labelled neurohormones is taken up by the brain, indicating a penetration of the blood-brain barrier and/or an accumulation within the structures of the barrier system.
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