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  • Title: Effect of 6-hydroxydopamine treatment on TSH secretion in basal and cold-stimulated conditions in the rat.
    Author: Schettini G, Quattrone A, Di Renzo G, Lombardi G, Preziosi P.
    Journal: Eur J Pharmacol; 1979 Jun; 56(1-2):153-7. PubMed ID: 467504.
    Abstract:
    6-Hydroxydopamine (6-OHDA) (two doses of 200 micrograms each, administered intraventricularly at a 48 h interval) caused a marked decrease of hypothalamic noradrenaline content and blocked the TSH rise elicited by cold exposure. Clonidine (0.4 mg/kg i.p.), a noradrenaline receptor agonist, was able to reverse the 6-OHDA of cold-induced TSH surge. The plasma TSH levels after cold stress in rats treated with 6-OHDA + clonidine were significantly higher than in vehicle + clonidine-injected animals, thus suggesting the presence of noradrenaline receptor supersensitivity in 6-OHDA-pretreated rats. 6-OHDA did not modify the basal concentrations of TSH but the administration of clonidine to 6-OHDA-injected animals caused a significant increase in thyrotropin secretion when compared with the vehicle + clonidine group.
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