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  • Title: Endogenous prostaglandins in peptic ulcer disease.
    Author: Baker R, Jaffe BM, Venables CW.
    Journal: Gut; 1979 May; 20(5):394-9. PubMed ID: 468069.
    Abstract:
    Plasma concentrations of prostaglandins E and F have been measured by radioimmunoassay in patients undergoing diagnostic upper intestinal endoscopy. The results fail to support a previously reported deficiency of plasma PGE in duodenal ulcer patients. Plasma prostaglandin concentrations failed to correlate with the parameters of gastric secretion studied; and were unaffected by histamine H2-receptor blockade or the activity of duodenal ulceration. During combined pentagastrin and insulin secretory studies there was a significant correlation between the outputs of PGE and acid into gastric juice.
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