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  • Title: Mechanism of action of vitamin K: demonstration of a liver precursor of prothrombin.
    Author: Suttie JW.
    Journal: Science; 1973 Jan 12; 179(4069):192-4. PubMed ID: 4682251.
    Abstract:
    Extracts of sonicated liver microsomes that are prepared from rats deficient in vitamin K or from rats given vitamin K antagonists contain a factor that liberates a thrombin-like activity when it is incubated with venom from Echis carinatus. The amount of this factor is low in control rats and in hypoprothrombinemic rats given vitamin K 1 hour before they were killed. These data indicate that this factor is a protein precursor of prothrombin, which is synthesized in the liver.
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