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  • Title: Episodic secretion of LH and FSH after ovariectomy. Secretory patterns in response to estrogen and progesterone.
    Author: Wallach EE, DeCherney AH, Russ D, Duckett G, Garcia CR, Root AW.
    Journal: Obstet Gynecol; 1973 Feb; 41(2):227-33. PubMed ID: 4684207.
    Abstract:
    Patterns of LH and FSH secretion were studied in menopausal and ovariectomized subjects by frequent sampling and the influence of ovarian steroids upon these patterns was observed. Subjects were 5 women who had been subjected to bilateral oophorectomy. At 8:00 AM of Study Day 1 (control day), after fasting since midnight, 5 ml of venous blood was drawn and samples were taken at 20 minute intervals thereafter for a period of 8 hours. Patency of the needle was maintained by a slow infusion of normal saline. Blood serum was stored at - 20 degrees C. The next day blood samples were similarly collected for 2 hours. Then, in 2 patients, at 10:00 AM estradiol benzoate 1 mg was administered in a single dose, after which blood samples were collected at 20 minute intervals for an additional 6 hours. On Day 3 the same procedure was followed, except that at 10:00 AM progesterone 100 mg was given in a single intravenous dose. In 3 other patients the order of steroid administration was reversed so that progesterone was given on Study day 2 and estradiol on Day 3. Serum LH and FSH concentrations were determined by double antibody radioimmunoassays. Serum LH and FSH concentrations were increased in all patients. During control periods serum LH levels fluctuated periodically in all subjects. Serum FSH concentration varied episodically in 2 patients. No synchronous pattern was noted either before or after the administration of the drugs. After estradiol was administered on Day 2 to 2 patients, serum LH concentrations declined 39-55% from pretreatment levels and serum FSH levels decreased 15-20%. In these patients episodic increases in both LH and FSH values were observed even after estradiol injection. When progesterone was given on Day 2 and estradiol on Day 3, serum LH concentrations declined promptly. Fluctuation of LH levels were apparent in 2 of the 3 patients. FSH levels declined in only 1. Progesterone alone had no effect on FSH levels. Steroids seem to modify release of gonadotrophin rather than exert sole control over gonadotrophin release.
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