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  • Title: Anti-receptor antibody. I. Isolation and characterization of the immunoglobulin receptor for phosphorylcholine.
    Author: Strayer DS, Vitetta ES, Köhler H.
    Journal: J Immunol; 1975 Feb; 114(2 pt 2):722-7. PubMed ID: 46887.
    Abstract:
    We have demonstrated a phosphorylcholine-binding protein in lysates from radioiodinated splenocytes of immunized mice. Immunoprecipitation with anti-receptor antibody of lysates from splenocytes obtained from animals undergoing a primary response or from mice immunized 4 to 6 months earlier with antigen demonstrated that this protein contained H and L chains. Therefore, we have isolated an antigen-specific receptor from the surface of spleen cells from both immunized and "memory" animals. This receptor Ig comprises approximately 10% of total cell surface Ig.
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