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  • Title: Lymphocyte transformation induced by autologous cells. II. Stimulation by mitogen-induced lymphoblasts.
    Author: Weksler ME.
    Journal: J Exp Med; 1973 Mar 01; 137(3):799-806. PubMed ID: 4689338.
    Abstract:
    Lymphocytes incubated with phytohemagglutinin or concanavalin A develop the capacity to stimulate autologous lymphocyte transformation. This is not attributable to residual mitogen contaminating the lymphoblastic cell preparation as: (a) the dissociation of mitogen from the lymphoblastic cell preparation increases the degree of stimulation observed and (b) the kinetics of lymphocyte transformation stimulated by phytohemagglutinin-induced lymphoblasts is different from that stimulated by phytohemagglutinin. The appearance of the stimulatory determinants on lymphocytes exposed to phytohemagglutinin precedes morphological transformation.
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