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  • Title: Leukocyte alkaline phosphatase monitoring of ovarian function in normal and clomiphene-treated cycles.
    Author: Polishuk WZ, Diamant YZ.
    Journal: Fertil Steril; 1973 Apr; 24(4):245-51. PubMed ID: 4694500.
    Abstract:
    Daily leukocyte alkaline phosphatase activity (LAP), basal body temperature (BBT), fern test (FT) and serum luteinizing hormone (LH) were determined during 15 normal menstrual cycles and 10 cycles treated with clomiphene citrate. A rise in LAP activity, as determined by LAP-relative score (LAP-RS), was observed during the midcycle period. This rise reached peak values on the day of serum LH surge in 60% of cycles. In the remaining cycles, LAP-RS showed peak values 1 day before (8%) or after (32%) LH peak. The mean LAP-RS peak value in clomiphene treated cycles was 13.2, 5-6 times higher than the basic value. The low point of the BBT coincided with the LH SURGE in only 32% of cycles. In 32% the span was more than 1 day before or after LH peak. The day of ovulation as determined by FT corresponded to the LH surge in only 40% of cycles. In 20% of cases, the ovulatory FT reponse occurred more than 1 day before or after LH surge. The results in this study indicated that LAP-RS is a rapid, simple and reliable test for timing of ovulation when carried out daily. It may be valuable in monitoring follicular activity during human chorionic gonadotropin therapy.
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