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  • Title: The termination of pregnancy by intravenous infusion of a synthetic prostaglandin F 2 analogue.
    Author: Sharp DS, Burslem RW.
    Journal: J Obstet Gynaecol Br Commonw; 1973 Feb; 80(2):138-41. PubMed ID: 4703809.
    Abstract:
    ICI 74 205, a synthetic analogue of prostaglandin F2 alpha (PGF2a) with an alkyl side chain extended by an ethyl group, was administered intravenously in 6 patients using normal saline as the vehicle. Starting dose was 5 mcg/minute in the 1st case and 10 mcg/minute in subsequent cases. Highest dose rate used in every case was 125 mcg/minute. All, except 1 patient, were in the second trimester of pregnancy. The other patient was in the first trimester of pregnancy. Diarrhea and vomiting, as well as a local cutaneous inflammatory reaction at the site of intravenous infusion, occurred in all patients during the infusion but disappeared after the infusion had been stopped. A fall in the plasma estradiol and progesterone levels was seen 2 hours after the start of the prostaglandin infusion. Five patients had a complete abortion. Abortion was incomplete in 1. Mean induction-abortion interval was 25 hours 15 minutes, with a range of from 7 hours 45 minutes to 49 hours 30 minutes. Although the results are encouraging, it is not possible to establish the effectiveness of ICI 74 205 because of the small series. Further research should be done to determine whether the initial uterine activity is due to a direct effect of prostaglandin on the uterine smooth muscle or whether the final outcome depends on changes reflected by the fall in plasma estrogen and progesterone level. Efficacy of ICI 74 205 in various dose regimens and other routes of administration should be investigated.
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