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  • Title: Clear-cell adenocarcinoma of the vagina in a girl whose mother had taken diethylstilbestrol.
    Author: Williams RR, Schweitzer RJ.
    Journal: Calif Med; 1973 Jun; 118(6):53-5. PubMed ID: 4709529.
    Abstract:
    This case study illustrates the delayed association of administration of synthetic nonsteroidal estrogen to mothers in early pregnancy with the postmenarchial onset of vaginal adenocarcinoma in their offspring. An 18-year-old-patient, whose mother had received 25 mg of diethylstilbestrol (DES) 4 times/day during the 1st 4 months of pregnancy, presented with irregular vaginal bleeding. Pelvic examination revealed circumferential thickening and induration of the posterior vaginal wall. The area was nodular to granular and discolored by irregular hemorrhages. 1 month after biopsy confirmation, a Wertheim hysterectomy with right salpingo-oophorectomy, vaginectomy, resection of the anterior rectal segment and including pelvic lymphadenectomy, was preformed. The left oviduct and ovary were preserved, and vaginal reconstruction was also carried out. Microscopical examination of the vaginal tumor revealed clear-cell adenocarcinoma confined to the vaginal wall (Stage 1). The patient progressed normally, and was discharged on the 16th postoperative day. She remains well.
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