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  • Title: Effect of intravenous prostaglandin E 2 on platelet function, coagulation, and fibrinolysis.
    Author: Howie PW, Calder AA, Forbes CD, Prentice CR.
    Journal: J Clin Pathol; 1973 May; 26(5):354-8. PubMed ID: 4714960.
    Abstract:
    Prostaglandin E(2) (PGE(2)) was infused intravenously to eight women for the termination of pregnancy and tests of platelet function: coagulation and fibrinolysis were studied before and during the infusion.Platelet adhesiveness, as measured by a cellophane membrane test-cell system, was significantly diminished by PGE(2), a change which was not noted by the glass-bead column technique. The administration of PGE(2) caused more rapid platelet disaggregation following ADP-induced aggregation but had no effect on the platelet count, collagen-induced aggregation, or platelet factor 3 activity. An increase in plasma antithrombin concentration and euglobulin lysis activity was also noted. These results support the concept that prostaglandin E(2) might have a role in the prevention of thrombosis.
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