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  • Title: The effects of diphenylhydantoin and potassium on the biological activity of ouabain in the guinea-pig heart.
    Author: Baskin SI, Dutta S, Marks BH.
    Journal: Br J Pharmacol; 1973 Jan; 47(1):85-96. PubMed ID: 4717023.
    Abstract:
    1. Diphenylhydantoin (DPH) and potassium significantly prevent ouabain intoxication without preventing the inotropic effects of ouabain in the guinea-pig isolated heart.2. The antiarrhythmic effect of DPH and K on ouabain-induced toxicity appears to be related to their ability to reduce ouabain accumulation by the myocardium and thereby prevent the intracellular Na and K changes which lead to the arrhythmic state.
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