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  • Title: Autoimmune haemolytic anaemia. VI. 51 Chromium survival studies in patients with different kinds of warm autoantibodies.
    Author: Borne AE von dem, Engelfriet CP, Reynierse E, Beckers D, van Loghem JJ.
    Journal: Clin Exp Immunol; 1973 Apr; 13(4):561-71. PubMed ID: 4717096.
    Abstract:
    The results of 51Cr red cell survival and organ sequestration studies in seventysix patients with autoimmune haemolytic anaemia are described. In patients with incomplete IgG and IgA warm autoantibodies increased red cell destruction to a varying degree and mainly spleen sequestration were found. In patients with IgM incomplete warm autoantibodies sequestration of red cells mainly in the liver was seen. Liver sequestration was also present in patients with cold agglutinins/haemolysis, sometimes accompanied by a significant spleen sequestration. In a number of patients with haemolytic autoantibodies, i.e. warm haemolysins and cold agglutinins/haemolysins, a biphasic 51Cr elimination curve was obtained. The cause of this type of survival curve is discussed. In patients in whom a positive direct anticomplement test was the only serological abnormality a normal 51Cr red cell life-span was found.
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