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  • Title: Glycolysis of heat damaged red cells in relation to common blood groups.
    Author: Baar S.
    Journal: Br J Exp Pathol; 1973 Jun; 54(3):322-8. PubMed ID: 4718271.
    Abstract:
    A study of glycolysis of red cells heated in their own plasma for 10 min at 48° has shown that heat treatment alone increased total glucose utilization of A2B cells by 12%, A1 cells by 11%, B cells by 9·3% and O cells by 11·9%. Subsequent incubation for 3 hours at 37° further increased glycolysis by an additional 88% for A2B cells, 39% for A1 cells, 68% for B cells and 41% for O cells, indicating that the rate of increased glucose utilization of the cells examined was quantitatively related to the degree of initial stimulation during heating. Aerobic glycolysis increased by 40% to 55% in A2B, A1 and O cells during heating; B cells showed only a 10% increase. Incubation at 37° following heating reversed the heat stimulus. A2B and A1 cells now showed a decrease of 33% and 36% while both B and O cells only showed a reduction of 17%. Lactate/glucose ratios are lowered both after heating and after subsequent incubation at 37°. ATP levels were reduced between 4% and 9% by heating at 48°. The greatest reduction occurred in the A1 cells, which also showed the greatest increase in glycolysis during this period. Subsequent incubation increased the ATP deficit to about 14% for B and O cells, 7% for A2B cells but 39% for A1 cells. The possible implications of the findings are discussed.
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