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  • Title: The effect of vaginally administered prostaglandin F2alpha on corpus luteum function.
    Author: Bolognese RJ, Corson SL.
    Journal: Am J Obstet Gynecol; 1973 Sep 15; 117(2):240-5. PubMed ID: 4728875.
    Abstract:
    In order to evaluate luteolytic activity, prostaglandin F2alpha (PGF2alpha) was administered intravaginally to 7 women in doses ranging from 125 to 400 mg during the late luteal phase of the cycle. The women ranged in age from 22-28 years. The women, with a history of regular menstrual cycles, were studied during 3 menstrual cycles (2 control and 1 treatment). Cycles were monitored by basal body temperature and daily blood samples from day 10 of the cycle to the day of menses. 24 and 48 hours following treatment with prostaglandin F2alpha, each woman received 3000 and 6000 I.U. of human gonadotropin (HCG) intramuscularly. Although there was a transient decrease in 5 subjects, progesterone levels increased after the HCG. The length of the cycle was prolonged significantly in 5 of 7 subjects. Slight vaginal bleeding was noted in 2 subjects immediately following treatment. 2 women experienced severe vomiting and diarrhea. The chemical profile in all 7 patients was unaffected by PGF2alpha administration.
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