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  • Title: Abortion of early pregnancy by the intravaginal administration of prostaglandin F2alpha.
    Author: Bolognese RJ, Corson SL.
    Journal: Am J Obstet Gynecol; 1973 Sep 15; 117(2):246-50. PubMed ID: 4728876.
    Abstract:
    A pilot study was conducted to ascertain the feasibility of using PG (prostaglandin) F2alpha as an intravaginal abortifacient at early gestations. 12 healthy women 7-17 days beyond their expected menstrual period were used as subjects. 4 were given a 50 mg/ml solution of PGF2alpha as an aqueous Tham salt solution every 2 hours for an 8-12 hour period. The other 8 received a 200 mg/ml solution at a dose of 50 mg every 2-3 hours for a 10-16 hour period. The 4 who received the weaker solution did not abort. 6 of the 8 who received the more concentrated solution aborted successfully. Gastrointestinal side effects were common but unrelated to the total dose of the drug received. This study proves the success of drug-induced abortion with PGs early in pregnancy. Further research is being done with PG administration through vaginal suppository. If this is successful, this type of abortion might be self-produced in the future.
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