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  • Title: Vitamin B12 and the megaloblastic development.
    Author: Haurani FI.
    Journal: Science; 1973 Oct 05; 182(4107):78-9. PubMed ID: 4730057.
    Abstract:
    In patients with vitamin B(12) deficiency, phytohemagglutinin-stimulated cultured lymphocytes had little or no thymidylate synthetase activity. Ample activity was found in such lymphocytes from normal individuals and patients with folic acid deficiency or pernicious anemia in remission. It therefore appears that the megaloblastosis that is associated with vitamin B(12) deficiency is related to low thymidylate synthetase activity.
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