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  • Title: [Composition and structure of the chief gangliosides in the brain of the lamprey Lampetra fluviatilis].
    Author: Avrova NF.
    Journal: Zh Evol Biokhim Fiziol; 1979; 15(4):332-8. PubMed ID: 473990.
    Abstract:
    It has been shown that 4-sphingenine is the main sphingoid in lamprey brain gangliosides. Saturated and monoenoic fatty acids were found to predominate, the main fatty acids in the lamprey brain are presented by stearic (43-49% of total fatty acids) and oleic ones. N-acetylneuraminic acid is the only sialic acid found in gangliosides from the lamprey brain. Other components of ganglioside molecules are glucose, galactose and N-acetylgalactosamine. Two main lamprey brain gangliosides which constitute more than 90% of lipid-bound sialic acid, were found to be trisialogangliosides. It was shown that both gangliosides have the following structure in their molecules: (formula see text). They differ in the position of two other sialic acid residues. Data on lamprey brain gangliosides in the literature are practically absent. The data obtained in the present study confirmed the conclusions on changes in the hydrophobic part of ganglioside molecule in evolution of vertebrates and made it possible to define more exactly the molecular evolution of ganglioside carbohydrate component.
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