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  • Title: Biosynthetic precursors of vitamin K as growth promoters for Bacteroides melaninogenicus.
    Author: Robins DJ, Yee RB, Bentley R.
    Journal: J Bacteriol; 1973 Nov; 116(2):965-71. PubMed ID: 4745437.
    Abstract:
    The growth of a vitamin K-requiring strain of Bacteroides melaninogenicus was promoted by some postulated and proven biosynthetic precursors of bacterial menaquinones, 1,4-dihydroxy-2-naphthoic acid, shikimic acid, chorismic acid, and 4(2'-carboxyphenyl)-4-oxobutyric acid. Growth of the organism with [2',4-(14)C(2)]-4(2'-carboxy phenyl)-4-oxobutyric acid as the vitamin K replacement gave rise to a mixture of radioactive menaquinone-9 and menaquinone-10; the dilution factor for this incorporation was 1.8.
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