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  • Title: Mammary carcinoma: enzymatic block in disialoganglioside biosynthesis.
    Author: Keenan TW, Morré DJ.
    Journal: Science; 1973 Nov 20; 182(4115):935-7. PubMed ID: 4745597.
    Abstract:
    The sialyl transferase of disialoganglioside formation is depressed in mammary tumors induced in the rat by 7,12-dimethylbenz[a]anthracene. Specific activities of other glycosyltransferases of the pathway ceramide to monosialo-ganglioside are unchanged or elevated so that the ganglioside GM(1) accumulates and higher gangliosides are depressed. These findings with a solid tumor are critical to an involvement of gangliosides in the cell-surface changes of tumorigenesis.
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