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  • Title: Marked hypodiploidy in a case of acute undifferentiated leukemia.
    Author: Como R, Sarna G, Sparkes RS.
    Journal: Am J Hematol; 1979; 6(2):143-7. PubMed ID: 474573.
    Abstract:
    A-29-year-old white man with acute undifferentiated leukemia had bone marrow cells with predominantly 42 chromosomes including several rearrangements. Following a brief induced "complete" remission, during which normal chromosomes were observed, bone marrow cells with 42 chromosomes but a different karyotype than before remission were found. Evaluation of that karyotype indicates not only a reduced chromosome count but also a reduced quantity of chromosome material.
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